Amanda Knox will present the comedy monologue "Amanda Knox: Cartwheel" at the Edinburgh Festival Fringe from August 7 to 17. The autobiographical show addresses Knox's legal ordeal following the murder of Meredith Kercher in Perugia in 2007, her conviction and subsequent definitive acquittal in 2015, as well as the theme of motherhood.

Stephanie Kercher, Meredith's sister, publicly expressed her opposition to the initiative in an interview on BBC Breakfast. She asked Knox to reflect on the family's suffering and said: "Think about our family, and try to reverse the situation, if it had happened to your sister." Stephanie Kercher also argued that the initiative risks setting a precedent for other shows centered on criminal cases involving victims and their families.

Amanda Knox responded to the criticism by telling the Telegraph newspaper that she does not joke about Meredith's death, but uses comedy to address difficult topics with sensitivity, referring in particular to her own experience of defamation. She also claimed that Meredith might have appreciated the show, describing her as an intelligent and refined person.

Criticism of the show has also come from the Kercher family's lawyer, Francesco Maresca, who called the initiative offensive and deplorable toward the victim's memory. A petition to stop the show, promoted by Manchester Mayor Andy Burnham, has gathered over 2,400 signatures.

Rudy Guede was definitively convicted for the murder of Meredith Kercher and served 13 of his 16-year sentence. Although the court established that Guede did not act alone, Italian prosecutors did not identify other perpetrators following the definitive acquittal of Knox and Raffaele Sollecito, issued by the Court of Cassation in 2015.